Genenta Update at SITC22 Indicates Potential for Anti-Tumor Immune System Reset after Temferon™ Treatment in Glioblastoma Patients
• Signs of intra-tumor pro-inflammatory state in patients
• Temferon™ induced immune system reset in preclinical studies
• Macrophage and T cell profiles in patients’ tumor microenvironment echo preclinical findings
Single cell sequencing analyses of the TME unveiled a pro-inflammatory reprogramming of the myeloid and T cells compartment of Temferon-treated patients. This pro-inflammatory pattern was associated in preclinical studies with tumor responses and in a fraction of mice with tumor eradication.
Pierluigi Paracchi, CEO of Genenta, said: "I am delighted that Genenta’s team and collaborators have been able to produce this positive data, suggesting the potential of Temferon as a disease-modifying intervention in glioblastoma where the unmet need is so high. When you show that Temferon can re-tune the immune status of the tumor and its immediate surroundings under such challenging conditions, many treatment possibilities emerge.”
Temferon, the Company’s cell-based interferon-alpha delivery product candidate, is an autologous HSC-based platform that delivers targeted interferon-alpha to the tumor microenvironment via Tie-2 expressing monocytes, with transcriptional and post-transcriptional control mediated by miRNA target sequences.
The aforementioned data will be presented as a poster [#192034] at SITC's 37th annual meeting taking place from
Genenta (www.genenta.com) is a clinical stage immuno-oncology company developing a cell-based platform harnessing the power of hematopoietic stem cells to provide durable and safe treatments for solid tumors. Our platform is not tumor type nor target antigen restricted and provides sustained targeted expression of therapeutic payload(s) inside the tumor micro-environment. Genenta’s lead product candidate, Temferon, precisely targets the delivery of interferon-alpha to the tumor micro-environment, minimizing systemic toxicity while breaking tumor-induced immune tolerance. Our treatments are designed as one-time monotherapies, but with the additional potential, when used in combination, to significantly enhance the efficacy of other approved therapeutics.
Statements in this press release contain “forward-looking statements,” within the meaning of the
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Source: Genenta Science